منابع مشابه
Animal and human carcinogens.
Lewis et al. (1) state that compared to the fairly large number (> 400) of known rodent carcinogens, only a relatively small number of compounds (-20-30) have been shown to be carcinogenic in humans. From this comparison, the authors seem to infer that animal bioassay cancer findings overpredict for human carcinogens. Of course, for most animal carcinogens there are no available epidemiologic d...
متن کاملNaming Carcinogens
Interventional studies have demonstrated the impact of hyperglycemia on the development of vascular complications associated with type 2 diabetes, which underscores the importance of safely lowering glucose to as near-normal as possible. Among the current challenges to reducing the risk of vascular disease associated with diabetes is the management of body weight in a predominantly overweight p...
متن کاملNatural carcinogens.
-Index sites of breast and cervix uteri were selected from populationbased data held at the West Midlands and Birmingham Regional Cancer Registry, and the expected numbers of second primary cancers in cervix and breast were computed (sequence analyses). In the breast series (17,756 patients) a small deficit of cervical tumours was observed (0=16, E=2-119, O/E=0-76, P>0005), while in the cervix ...
متن کاملChildhood cancers and atmospheric carcinogens.
STUDY OBJECTIVES To retest previous findings that childhood cancers are probably initiated by prenatal exposures to combustion process gases and to volatile organic compounds (VOCs); and to identify specific chemical hazards. DESIGN Birth and death addresses of fatal child cancers in Great Britain between 1966 and 1980, were linked with high local atmospheric emissions of different chemical s...
متن کاملAre genotoxic carcinogens more potent than nongenotoxic carcinogens?
In this report we have raised the question whether genotoxic carcinogens are more potent than nongenotoxic carcinogens when studied in long-term carcinogenicity assays in rodents. To build a large database of compounds for which both carcinogenicity and genotoxicity had been investigated, we have used a database produced by Gold and co-workers for carcinogenic potency data (975 chemicals) and a...
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ژورنال
عنوان ژورنال: Nature
سال: 1977
ISSN: 0028-0836,1476-4687
DOI: 10.1038/267306b0